Jmjd6 CLIA Kit for Mouse(Mus musculus) | EIAab.comJmjd6 CLIA Kit for Mouse(Mus musculus)

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Jmjd6 (Gene name),

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (Protein name ), JMJD6_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Jmjd6(Kiaa0585;Ptdsr);

Protein name:

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6;

Alternative:

JmjC domain-containing protein 6;Histone arginine demethylase JMJD6;Lysyl-hydroxylase JMJD6;Jumonji domain-containing protein 6;Phosphatidylserine receptor(Protein PTDSR);Peptide-lysine 5-dioxygenase JMJD6;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with LUC7L2 and LUC7L3 (By similarity). Interacts with U2AF2/U2AF65.

Function:

Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

Subcellular Location:

Nucleus nucleoplasm Nucleus nucleolus Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.

Protein Attributes:

Sequence length:

403

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

403:

SSR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.383423

UniGene:

Mm.481684

SMR:

Q9ERI5

String:

Q9ERI5

KEGG:

mmu:107817

Pfam:

PF02373

Uniprot:

Q9ERI5

FOR

ELISA Kit for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

E1916h

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96T

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ELISA Kit for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

E1916m

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Packing:

96T

ELISA Kit for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

E1916r

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96T

ELISA Kit for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

E1916b

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96T

ELISA Kit for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

E1916c

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96T

CLIA Kit for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

U1916c

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96T

CLIA Kit for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

U1916m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

U1916h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

U1916r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

U1916b

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MSDS:

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96T

Polyclonal Antibody for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

P1916Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

P1916Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Cat.:

P1916Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Monoclonal Antibody for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Protein for Mouse Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A receptor for phosphatidylserine-specific clearance of apoptotic cells."
Fadok V.A. , Bratton D.L. , Rose D.M. , Pearson A. , Ezekewitz R.A. , Henson P.M.
Nature405:85-90(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: Swiss Webster.
tissue: Brain.
2.

"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Aizawa H. , Yuasa S. , Nakajima D. , Nagase T. , Ohara O. , Koga H.
DNA Res.10:35-48(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: 129.
tissue: Mammary tumor.
5.

"Phosphatidylserine receptor is required for clearance of apoptotic cells."
Li M.O. , Sarkisian M.R. , Mehal W.Z. , Rakic P. , Flavell R.A.
Science302:1560-1563(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
6.

"Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor."
Kunisaki Y. , Masuko S. , Noda M. , Inayoshi A. , Sanui T. , Harada M. , Sasazuki T. , Fukui Y.
Blood103:3362-3364(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
7.

"Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals."
Cui P. , Qin B. , Liu N. , Pan G. , Pei D.
Exp. Cell Res.293:154-163(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
8.

"The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal."
Boese J. , Gruber A.D. , Helming L. , Schiebe S. , Wegener I. , Hafner M. , Beales M. , Koentgen F. , Lengeling A.
J. Biol.3:15.1-15.18(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
9.

"Hide and seek: the secret identity of the phosphatidylserine receptor."
Williamson P. , Schlegel R.A.
J. Biol.3:14.1-14.4(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
10.

"Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1."
Boeckel J.N. , Guarani V. , Koyanagi M. , Roexe T. , Lengeling A. , Schermuly R.T. , Gellert P. , Braun T. , Zeiher A. , Dimmeler S.
Proc. Natl. Acad. Sci. U.S.A.108:3276-3281(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH U2AF2

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